Hatakeyama Lab. [Department of Microbiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo]



Published in Scientific Reports !

Hashi, K. et al.
Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. Scientific Reports 8, Article No: 15981 (2018)

The 37th Sapporo International Cancer Symposium is held on July 17-19 in Sapporo, Japan. We now call for abstracts of poster presentations. SCS2018 posterClick to view PDF(2.8 MB)

Published in iScience !

Tang, C. et al.
Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin. iScience 1, p1-15 (2018)

Published in Cell Reports !

Hayashi, T. et al.
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Reports 20(12): 2876-90 (2017)

Published in Toxins !

Nishikawa, H., Hatakeyama, M.
Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein. Toxins 9(4), 136 (2017)

Published in Nature Communications !

Kikuchi, I. et al.
Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nature Communications 7, Article No: 12887 (2016)

Published in Scientific Reports !

Nishikawa, H. et al.
Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b. Scientific Reports 6, Article No: 30031 (2016)

Published in Cancer Science !

Senda, Y. et al.
Csk-mediated EPIYA phosphorylation of Pragmin creates a feed-forward Csk activation loop that promotes cell motility. Cancer Sci, in press

Published in Nature Microbiology !

Saju, P. et al.
Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV. Nature Microbiology Article Number: 16026 (2016)

Published in Scientific Reports !

Shimoda, A. et al.
Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA. Scientific Reports 6: 18346 (2016)

Published in BBRC !

Noda, S. et al.
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling. Biochem Biophys Res Commun, in press

Published in Scientific Reports !

Nagase, L. et al.
Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis. Scientific Reports 5: 15749 (2015)

Published in Scientific Reports !

Suzuki, N., Murata-Kamiya, N. et al.
Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. Scientific Reports 5: 10024 (2015)

Published in Cell Host & Microbe !

Hatakeyama, M.
Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis. Cell Host Microbe 15(3): 306-316 (2014)

Published in Cancer Science !

Hashi K. et al.
A natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1. Cancer Sci, in press (2013)

Published in Developmental Cell !

Tsutsumi, R., et al.
YAP and TAZ, Hippo Signaling Targets, Act as a Rheostat for Nuclear SHP2 Function.
Developmental Cell, in press (2013)

Published in PNAS !

Fujii, Y., et al.
CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
Proc. Natl. Acad. Sci. U. S. A. 109, 20584-20589 (2012)

published in Cell Adhesion & Migration !

Yamahashi, Y & Hatakeyama, M.
PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein
Cell Adh. Migr., in press (2012)

Published in Cellular Microbiology !

Hayashi, T. et al.
Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?
Cell. Microbiol., in press (2012)

Published in Cell Host & Microbe
Hayashi, T., et al. Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA. Cell Host Microbe 12(1): 20-33 (2012)

This paper is the most downloaded article in the Cell Host & Microbe for the 30 days preceding July 30, 2012.

PDB ID: 4DVY, 4DVZ (Release: 2012-07-25)

This paper is previewed by Backert & Tegtmeyer in the same issue.

Published in Microbes and Infection
Kikuchi, K., et al. Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling. Microbes Infect. 14(5): 470-476 (2012)
Published in Journal of Biological Chemistry
Yamahashi, Y., et al. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization. J. Biol. Chem.286(52): 44576-84 (2011)
Published in PNAS
Safari, F., et al. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Proc. Natl. Acad. Sci. U. S. A. 108(36): 14938-43 (2011)
Published in Journal of Biological Chemistry
Nagase L., et al. Potentiation of Helicobacter pylori CagA virulence through homodimerization. J. Biol. Chem. 286(38): 33622-31 (2011)
Published in Molecular Cell
Takahashi, A., et al.
SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.
Mol. Cell 43(1):45-56 (2011)

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