畠山研究室 【東京大学大学院医学系研究科・医学部 病因・病理学専攻 微生物学講座 微生物学研究室】

研究業績

2020

  1. Ooki, T., Hatakeyama, M. Hyaluronan Degradation Promotes Cancer via Hippo-YAP Signaling: An Intervention Point for Cancer Therapy. Bioessays, in press (2020) [Abstract-MEDLINE]
  2. Fujii, Y., Murata-Kamiya, N., Hatakeyama, M. Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells. Cancer Sci. 111(5): 1596-1606 (2020) [Abstract-MEDLINE]
  3. Takahashi-Kanemitsu, A., Knight, C.T., Hatakeyama, M. Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpins gastric carcinogenesis. Cell. Mol. Immunol. 17(1): 50-63 (2020) [Abstract-MEDLINE]
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2019

  1. Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M., Suzuki, H. Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori-Infected CAPZA1-Overexpressing Cells. Cell. Mol. Gastroenterol. Hepatol. 8(3): 319-334 (2019) [Abstract-MEDLINE]
  2. Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., Hosoda, F., Rokutan, H., Matsumoto, M., Takamaru, H., Yamada, M., Matsuda, T., Iwasaki, M., Yamaji, T., Yachida, T., Soga, T., Kurokawa, K., Toyoda, A., Ogura, Y., Hayashi, T., Hatakeyama, M., Nakagama, H., Saito, Y., Fukuda, S., Shibata, T., Yamada, T. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat. Med. 25(6): 968-76 (2019) [Abstract-MEDLINE]
  3. Knorr, J., Ricci, V., Hatakeyama, M., Backert, S. Classification of Helicobacter pylori Virulence Factors: Is CagA a Toxin or Not?. Trends in Microbiol. 27(9): 731-8 (2019) [Abstract-MEDLINE]
  4. Ooki, T., Murata-Kamiya, N., Takahashi-Kanemitsu, A., Wu, W. and Hatakeyama, M. High-molecular-weight hyaluronan is a Hippo pathway ligand that directs cell density-dependent growth inhibition via PAR1b. Dev. Cell 49(4): 590-604 (2019) [Abstract-MEDLINE]
  5. Hatakeyama, M. Malignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma. Adv. Exp. Med. Biol. 1-15 (2019) [Abstract-MEDLINE]

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2018

  1. Hashi, K., Imai, C., Yahara, K., Tahmina, K., Hayashi, T., Azuma, T., Miyabe-Nishiwaki, T., Sato, H., Matsuoka, M., Niimi, S., Okamoto, M., Hatakeyama, M. Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. Sci. Rep. 8(1), Article number: 15981 (2018) [Abstract-MEDLINE]
  2. Tang, C., Takahashi-Kanemitsu, A., Kikuchi, I., Ben, C., Hatakeyama, M. Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin. iScience 1: 1-15 (2018) [Abstract-MEDLINE]

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2017

  1. Hayashi, T., Senda, M., Suzuki, N., Nishikawa, H., Ben, C., Tang, C., Nagase, L., Inoue, K., Senda, T., Hatakeyama, M. Differential mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA oncoproteins. Cell Reports 20(12): 2876-90 (2017) [Abstract-MEDLINE] [UTokyo Focus]
  2. Hatakeyama, M. Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 93(4): 196-219 (2017) [Abstract-MEDLINE]
  3. Nishikawa, H., Hatakeyama, M. Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein. Toxins 9(4), pii: E136 (2017) [Abstract-MEDLINE]
  4. Shiroki, T., Yokoyama, M., Tanuma, N., Maejima, R., Tamai, K., Yamaguchi, K., Oikawa, T., Noguchi, T., Miura, K., Fujiya, T., Shima, H., Sato, I., Murata-Kamiya, N., Hatakeyama, M., Iijima, K., Shimosegawa, T., Satoh, K. The enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism. Cancer Sci. 108(5): 931-40 (2017) [Abstract-MEDLINE]

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2016

  1. Nakano, M., Yahiro, K., Yamasaki, E., Kurazono, H., Akada, J., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T., Moss, J., Isomoto, H., Hirayama, T. Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagAphosphorylation in human duodenum carcinoma cell line AZ-521. Dis. Model. Mech. 9(12): 1473-81 (2016) [Abstract-MEDLINE]
  2. Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P.J., Noda, S., Nakao, K., Kasai, H., Sato, T., Aiba, A., Hatakeyama, M. Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nat. Commun. 7, Article Number: 12887 (2016) [Abstract-MEDLINE] [UTokyo Focus]
  3. Nishikawa, H., Hayashi, T., Arisaka, F., Senda, T., Hatakeyama, M. Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b. Sci. Rep. 6, Article Number: 30031 (2016) [Abstract-MEDLINE] [UTokyo Focus]
  4. Roy, R.K., Hoppe, M.M., Srivastava, S., Samanta, A., Sharma, N., Tan, K.T., Yang, H., Voon, D.C., Pang, B., Teh, M., Murata-Kamiya, N., Hatakeyama, M., Chang, Y.T., Young, W.P., Ito, Y., Ho, K.Y., Tan, P., Soong, R., Koeffler, P.H., Yeoh, K.G., Jeyasekharan, A.D. CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer. Oncotarget 7(34): 55290-301 (2016) [Abstract-MEDLINE]
  5. Senda, Y., Murata-Kamiya, N., Hatakeyama, M. Csk-mediated EPIYA phosphorylation of Pragmin creates a feed-forward Csk activation loop that promotes cell motility. Cancer Sci. 107(7): 972-80 (2016) [Abstract-MEDLINE]
  6. Saju, P., Murata-Kamiya, N., Hayashi, T., Senda, Y., Nagase, L., Noda, S., Matsusaka, K., Funata, S., Kunita, A., Urabe, M., Seto, Y., Fukayama, M., Kaneda, A., Hatakeyama, M. Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus. Nat. Microbiol. Article number: 16026 (2016) [Abstract-MEDLINE] [Nature Microbiology, News & Views] [UTokyo Focus] [東京大学プレスリリース]
  7. Lang, B.J., Gorrell, R.J., Tafreshi, M., Hatakeyama, M., Kwok, T., Price, J.T. The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression. Cell Stress Chaperones 21(3): 523-33 (2016) [Abstract-MEDLINE]
  8. Kameoka, S., Kameyama, T., Hayashi, T., Seto, S., Ohnishi, N., Hayashi, T., Murata-Kamiya, N., Higashi, H., Hatakeyama, M., Takaoka, A. Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells. Biomed. Res. 37(1): 21-27 (2016) [Abstract-MEDLINE]
  9. Senda, M., Hayashi, T., Hatakeyama, M., Takeuchi, K., Sasaki, A.T., Senda, T. Use of multiple cryoprotectants to improve diffraction quality from protein crystals. Cryst. Growth Des. 16(3): 1565-71 (2016) [ACS Publications] [KEK物構研プレスリリース]
  10. Shimoda, A., Ueda, K., Murata-Kamiya, N., Mukai, S., Sawada, S., Azuma, T., Hatakeyama, M* and Akiyoshi, K*. Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA. Sci. Rep. 6: 18346 (2016) [Abstract-MEDLINE] (*Corresponding authors)

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2015

  1. Noda, S., Takahashi, A., Hayashi, T., Tanuma, S. and Hatakeyama, M.Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling. Biochem. Biophys. Res. Commun. 469(4): 1133-9 (2016) [Abstract-MEDLINE]
  2. Nagase, L., Hayashi, T., Senda, T. and Hatakeyama, M. Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis. Sci. Rep. 5: 15749 (2015) [Abstract-MEDLINE]
  3. Suzuki, N., Murata-Kamiya, N., Yanagiya, K., Suda, W., Hattori, M., Kaneda, H., Bingo, A., Fujii, Y., Maeda, S., Koike, K. and Hatakeyama, M. Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. Sci. Rep. 5: 10024 (2015) [Abstract-MEDLINE]

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2014

  1. Hatakeyama, M. Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis. Cell Host Microbe 15(3): 306-16 (2014) [Abstract-MEDLINE]
  2. Bessède, E., Staedel, C., Acuña Amador, L.A., Nguyen, P.H., Chambonnier, L., Hatakeyama, M., Belleannée, G., Mégraud, F., Varon, C. Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes. Oncogene 33: 4123-31 (2014) [Abstract-MEDLINE]
  3. Hashi, K., Murata-Kamiya, N., Varon, C., Megraud, F., Domiguez-Bello, M.G., Hatakeyama, M. A natural variant of the Helicobacter pylori CagA oncoprotiein that lost the ability to interact with PAR1. Cancer Sci. 105(3): 245-51 (2014) [Abstract-MEDLINE]

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2013

  1. Tsutsumi, R., Masoudi, M., Takahashi, A., Fujii, Y., Hayashi, T., Kikuchi, I., Satou, Y., Taira, M., and Hatakeyama, M. YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function. Dev. Cell 26(6): 658-65 (2013) [Abstract-MEDLINE][ライフサイエンス新着論文レビュー]
  2. Miura, K., Wakayama, Y., Tanino, M., Orba, Y., Sawa, H., Hatakeyama, M., Tanaka, S., Sabe, H., and Mochizuki, N. Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. Oncogene 32(45): 5292-301 (2013) [Abstract-MEDLINE]
  3. Hayashi, T., Morohashi, H., and Hatakeyama, M. Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going? Cell. Microbiol. 15(3): 377-85 (2013) [Abstract-MEDLINE]
  4. Yamahashi, Y. and Hatakeyama, M. PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein. Cell Adh. Migr.7(1): 11-17 (2013) [Abstract-MEDLINE]

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2012

  1. Tsugawa, H., Suzuki, H. Seya, H., Hatakeyama, M., Hirayama, T., Hirata, K., Nagano, O., Matsuzaki, J., and Hibi, T. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe 12(6): 764-77 (2012) [Abstract-MEDLINE]
  2. Fujii, Y., Yoshihashi, K., Suzuki, H., Tsutsumi, S., Mutoh, H., Maeda, S., Yamagata, Y., Seto, Y., Aburatani, H., and Hatakeyama, M. CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemnes-associated reprogramming factors SALL4 and KLF5. Proc. Natl. Acad. Sci. U. S. A. 109: 20584-9 (2012)[Abstract-MEDLINE]
  3. Hayashi, T., Senda, M., Morohashi, H., Higashi, H., Horio, M., Kashiba, Y., Nagase, L., Sasaya, D., Shimizu, T., Venugopalan, N., Kumeta, H., Noda, N.N., Inagaki, F., Senda, T., and Hatakeyama, M. Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA. Cell Host Microbe 12(1): 20-33 (2012) [Abstract-MEDLINE] [Preview by Backert and Tegtmeyer][ライフサイエンス新着論文レビュー] [Faculty of 1000 Recommendations] [PDB ID: 4DVY, 4DVZ ]
  4. Lee, K. S., Kalantzis, A., Jackson, C. B., O'Connor. L., Murata-Kamiya, N., Hatakeyama, M., Judd, L. M., Giraud, A. S., Menheniott, T. R. Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation. PLoS One 7(2): e30786 (2012) [Abstract-MEDLINE]
  5. Kikuchi, K., Murata-Kamiya, N., Kondo, S., Hatakeyama, M. Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling. Microbes Infect. 14(5): 470-6 (2012) [Abstract-MEDLINE]

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2011

  1. Yamahashi, Y., Saito, Y., Murata-Kamiya, N., Hatakeyama, M. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization. J. Biol. Chem. 286(52): 44576-84 (2011) [Abstract-MEDLINE]
  2. Safari, F., Murata-Kamiya, N., Saito, Y., Hatakeyama, M. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Proc. Natl. Acad. Sci. U. S. A. 108(36): 14938-43 (2011) [Abstract-MEDLINE]
  3. Furuta, Y., Yahara, K., Hatakeyama, M., Kobayashi I. Evolution of cagA Oncogene of Helicobacter pylori through Recombination. PLoS One 6(8): e23499 (2011) [Abstract-MEDLINE]
  4. Nagase, L., Murata-Kamiya, N., Hatakeyama, M. Potentiation of Helicobacter pylori CagA virulence through homodimerization. J. Biol. Chem., 286(38): 33622-31 (2011) [Abstract-MEDLINE]
  5. Murata-Kamiya, N. Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori. Microbes Infect. 13(10): 799-807 (2011) [Abstract-MEDLINE]
  6. Takahashi, A., Tsutsumi, R., Kikuchi, I., Obuse, C., Saito, Y., Seidi, A., Karisch, R., Fernandez, M., Cho, T., Ohnishi, N., Rozenblatt-Rosen, O., Meyerson, M., Neel, B.G., Hatakeyama, M. SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver. Mol. Cell 43(1): 45-56 (2011) [Abstract-MEDLINE] [ライフサイエンス新着論文レビュー][CANCER DISCOVERY@AACR]
  7. Hatakeyama, M. Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein. Cancer Sci. 102(1): 36-43 (2011) [Abstract-MEDLINE]

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2010

  1. Saito, Y., Murata-Kamiya, N., Hirayama, T., Ohba, Y., Hatakeyama, M. Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. J. Exp. Med. 207(10): 2157-2174 (2010) [Abstract-MEDLINE]
  2. Murata-Kamiya, N., Kikuchi, K., Hayashi, T., Higashi, H., Hatakeyama, M. Helicobacter pylori Exploits Host Membrane Phosphatidylserine for Delivery, Localization, and Pathophysiological Action of the CagA Oncoprotein. Cell Host Microbe 7(5): 399-411 (2010) [Abstract-MEDLINE]
  3. Ding, S.Z., Goldberg, J.B., Hatakeyama, M. Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol. 6(5): 851-62 (2010) [Abstract-MEDLINE]
  4. Ding, S.Z., Fischer, W., Kaparakis-Liaskos, M., Liechti, G., Merrell, D.S., Grant, P.A., Ferrero, R.L., Crowe, S.E., Haas, R., Hatakeyama, M., Goldberg, J.B. Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoS One 1;5(4): e9875 (2010) [Abstract-MEDLINE]
  5. Tanaka, H., Yoshida, M., Nishiumi, S., Ohnishi, N., Kobayashi, K., Yamamoto, K., Fujita, T., Hatakeyama, M., Azuma, T. The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice. Arch. Biochem. Biophys. 498(1): 35-42 (2010) [Abstract-MEDLINE]

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2009

  1. Lamb, A., Yang, X.D., Tsang, Y.H., Li, J.D., Higashi, H., Hatakeyama, M., Peek, R.M., Blanke, S.R., Chen, L.F. Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep. 10(11):1242-9 (2009) [Abstract-MEDLINE]
  2. Miura, M., Ohnishi, N., Tanaka, S., Yanagiya, K. and Hatakeyama, M. Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice. Int. J. Cancer 125(11): 2497-504 (2009) [Abstract-MEDLINE]
  3. Ishikawa, S., Ohta, T. and Hatakeyama, M. Stability of Helicobacter pylori CagA oncoprotein in human gastric epithelial cells. FEBS Letters 583(14): 2414-8 (2009) [Abstract-MEDLINE]
  4. Lu, H., Murata-Kamiya, N., Saito, Y. and Hatakeyama, M. Role of PAR1/MARK kinases in the morphogenetic activity of Helicobacter pylori CagA. J. Biol Chem. 284(34): 23024-36 (2009) [Abstract-MEDLINE]
  5. Umeda, M., Murata-Kamiya, N., Saito Y., Ohba, Y., Takahashi, M. and Hatakeyama, M. Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. J. Biol. Chem. 284(33): 22166-72 (2009) [Abstract-MEDLINE]
  6. Hatakeyama M. Helicobacter pylori and gastric carcinogenesis. J. Gastroenterol 44(4): 239-48 (2009) [Abstract-MEDLINE]

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2008

  1. Hatakeyama M. Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA. Oncogene 27(55): 7047-54 (2008) [Abstract-MEDLINE]
  2. Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, Hatakeyama M. Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA. Cancer Sci. 99(10): 2004-11 (2008) [Abstract-MEDLINE]
  3. Nakayama, M., Hisatsune, J., Yamasaki, E., Isomoto, H., Kurazono, H., Hatakeyama, M., Azuma, T., Yamaoka, Y., Yahiro, K., Moss, J., Hirayama, T. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J. Biol. Chem. 284(3): 1612-9 (2008) [Abstract-MEDLINE]
  4. Nakajima, J., Ishikawa, S., Hamada, JI., Yanagihara, M., Koike, T., Hatakeyama, M. Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation. Biochem. Biophys. Res. Commun. 370(1): 189-94 (2008) [Abstract-MEDLINE]
  5. Hatakeyama, M. SagA of CagA in Helicobacter pylori pathogenesis. Curr. Opin. Microbiol. 11(1): 30-7 (2008) [Abstract-MEDLINE]
  6. Miyamoto, D., Miyamoto, M., Takahashi, A., Yomogita, Y., Higashi, H., Kondo, S., Hatakeyama, M. Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors. Oncogene 27(25): 3508-15 (2008) [Abstract-MEDLINE]
  7. Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., Yamada, G., Azuma, T., Hatakeyama, M. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc. Natl. Acad. Sci. U. S. A. 105(3): 1003-8 (2008) [Abstract-MEDLINE]
  8. Kurashima, Y., Murata-Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., Hatakeyama, M. Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence. Int J Cancer 122(4): 823-31 (2008) [Abstract-MEDLINE]

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2007

  1. Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S. and Hatakeyama, M. Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330-3 (2007) [Abstract-MEDLINE]
  2. Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R.M., Jr., Azuma, T. and Hatakeyama, M. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 26(32): 4617-26 (2007) [Abstract-MEDLINE]

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2006

  1. Hatakeyama, M. The Role of Helicobacter pylori CagA in Gastric Carcinogenesis. Int J Hematol. 84(4): 301-8 (2006) [Abstract-MEDLINE]
  2. Ren, S., Higashi, H., Lu, H., Azuma, T. and Hatakeyama, M. Structural Basis and Functional Consequence of Helicobacter pylori CagA Multimerization in Cells. J. Biol. Chem. 281(43): 32344-52 (2006) [Abstract-MEDLINE]
  3. Hatakeyama, M. Helicobacter pylori CagA - a bacterial intruder conspring gastric carcinogenesis. Int J Cancer 119(6): 1217-23 (2006) [Abstract-MEDLINE]
  4. Hatakeyama, M. and Brzozowski, T. Pathogenesis of Helicobacter pylori Infection. Helicobacter 11 Suppl 1: 14-20 (2006) [Abstract-MEDLINE]
  5. Ueda, H., Ito, M., Eguchi, H., Tanaka, S., Yoshihara, M., Haruma, K., Hatakeyama, M. and Chayama K. Development of a novel method to detect Helicobacter pylori cagAgenotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. Digestion 73(1): 47-53 (2006) [Abstract-MEDLINE]
  6. Naito, M., Yamazaki, T., Tsutsumi, R., Higashi, H., Onoe, K., Yamazaki, S., Azuma, T. and Hatakeyama, M. Influence of EPIYA-repeat Polymorphism on the Phosphorylation-dependent Biological Activity of Helicobacter pylori CagA. Gastroenterology 130(4): 1181-90 (2006) [Abstract-MEDLINE]
  7. Tsutsumi, R., Takahashi, A., Azuma, A., Higashi, H. and Hatakeyama, M. Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA. Mol. Cell. Biol. 26: 261-276 (2006) [Abstract-MEDLINE]

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2005

  1. Hatakeyama, M. and Higashi, H. Helicobacter pylori CagA - a new paradigm for bacterial carcinogenesis. Cancer Sci. 96(12): 835-43 (2005) [Abstract-MEDLINE]
  2. Nakano, N., Urasawa, K., Takagi, Y., Saito, T., Kaneta, S., Ishikawa, S., Higashi, H., Tsutsui, H., Hatakeyama, M. and Kitabatake, A. Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 338(3): 1661-7 (2005) [Abstract-MEDLINE]
  3. Yokoyama, K., Higashi, H., Ishikawa, S., Fujii, Y., Kondo, S., Kato, H., Azuma, T., Wada, A., Hirayama, T., Aburatani, H. and Hatakeyama, M. Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 102(27): 9661-6 (2005) [Abstract-MEDLINE]
  4. Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L., Perez-Perez, G. I., Hatakeyama, M., Whitehead, R., Gaus, K., O'brien, D. P., Romero-Gallo, J. and Peek, R. M., Jr. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc. Natl. Acad. Sci. U. S. A. 102(30): 10646-51 (2005) [Abstract-MEDLINE]
  5. Yanagihara, M., Ishikawa, S., Naito, M., Nakajima, J., Aburatani, H. and Hatakeyama, M. Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene. Oncogene 24(38): 5878-87 (2005) [Abstract-MEDLINE]
  6. Higashi, H., Yokoyama, K., Fujii, Y., Ren, S., Yuasa, H., Saadat, I., Murata-Kamiya, N., Azuma, T. and Hatakeyama, M. EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells. J. Biol. Chem. 280(24): 23130-7 (2005) [Abstract-MEDLINE]
  7. Yamazaki, S., Yamakawa, A., Okuda, T., Ohtani, M., Suto, H., Ito, Y., Yamazaki, Y., keida, Y., Higashi, H., Hatakeyama, M. and Azuma, T. Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. J. Clin. Microbiol. 43(8): 3906-16 (2005) [Abstract-MEDLINE]
  8. Yamazaki,S., Kato, S., Matsukura, N., Ohtani, M., Ito, Y., Suto, H., Yamazaki, Y., Yamakawa, A., Tokudome, S., Higashi, H., Hatakeyama, M. and Azuma, T. Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic tool. FEMS Immunol. Med. Microbiol. 44: 261-268 (2005) [Abstract-MEDLINE]

▲ページの先頭へ

2004

  1. Hatakeyama, M. Oncogenic mechanism of Helicobacter pylori CagA protein. Nature Rev. Cancer. 4: 688-694 (2004) [Abstract-MEDLINE]
  2. Azuma, T., Ohtani, M., Yamazaki, Y., Higashi, H. and Hatakeyama, M. Meta-analysis of relationship between CagA seropositivity and gastric cancer. Gastroenterology 126: 1927-1928 (2004) [Abstract-MEDLINE]
  3. Ozawa, H., Ashizawa, S., Naito, M., Yanagihara, M., Ohnishi, N., Maeda, T., Matsuda, Y., Higashi, H., Kakita, A. and Hatakeyama, M. The paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation. Oncogene 23: 6590-6602 (2004) [Abstract-MEDLINE]
  4. Sakurai, A., Yasuda, J., Takano, H., Tanaka, Y., Hatakeyama, M. and Shida, H. Regulation of human T-cell leukemia virus type 1 (HTLV-1) budding by ubiquitin ligase Nedd4. Microbes Infect. 6(2): 150-6 (2004) [Abstract-MEDLINE]
  5. Higuchi, M.,Tsutsumi, R., Higashi, H., Hatakeyama, M. Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cag A-positive Helicobacter pylori pathogenicity. Cancer Science 95(5): 442-7 (2004) [Abstract-MEDLINE]
  6. Higashi, H., Nakaya, A., Tsutsumi, R., Yokoyama, K., Fujii, Y., Ishikawa, S., Higuchi, M., Takahashi, A., Kurashima, Y., Teishikata, Y., Tanaka, S., Azuma, T., Hatakeyama, M. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J. Biol. Chem. 279(17): 17205-16 (2004) [Abstract-MEDLINE]
  7. Zhou, W., Yamazaki, S., Yamakawa, A., Ohtani, M., Ito, Y., Keida, Y., Higashi, H., Hatakeyama, M., Si, J., Azuma, T. The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. FEMS Immunol. Med. Microbiol. 40(1): 81-7 (2004) [Abstract-MEDLINE]
  8. Azuma, T., Yamazaki, S., Yamanaka, A., Ohtani, M., Muramatsu, A., Suto, H., Ito, Y., Dojo, M., Yamazaki, Y., Kuriyama, M., Keida, Y., Higashi, H. and Hatakeyama M. Association between Diversity in the Src Homology 2 Domain-Containing Tyrosine Phosphatase Binding Site of Helicobacter pylori CagA Protein and Gastric Atrophy and Cancer. J. Infect. Dis. 189(5): 820-7 (2004) [Abstract-MEDLINE]

▲ページの先頭へ

2003

  1. Umehara, S., Higashi, H., Ohnishi, N., Asaka, M. and Hatakeyama M. The Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma. Oncogene 22(51): 8337-42 (2003) [Abstract-MEDLINE]
  2. Azuma, T., Yamazaki, S., Yamanaka, A., Ito, Y., Ohtani, M., Dojo, M., Yamazaki, Y., Higashi, H. and Hatakeyama M. The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epitherial cells. Aliment. Pharmacol. Ther. 18: (Suppl.1)1-6 (2003) [Abstract-MEDLINE]
  3. Takebayashi, T., Higashi, H., Sudo, H., Ozawa, H., Suzuki, E., Shirado, O., Katoh H. and Hatakeyama M. NF-kB-dependent induction of cyclin D1 by pRB family proteins and tumor-derived pRB mutants. J. Biol. Chem. 278(17): 14897-905 (2003) [Abstract-MEDLINE]
  4. Tsutsumi, R., Higashi, H., Higuchi, M., Okada, M. and Hatakeyama, M. Attenuation of Helicobacter pylori CagA-SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase. J. Biol. Chem. 278(6): 3664-70 (2003) [Abstract-MEDLINE]
  5. Yamazaki, S., Yamakawa, A., Ito, Y., Ohtani, M., Higashi, H., Hatakeyama, M. and Azuma, T. The CagA protein of Helicobacter pylori is translocated into epitherial cells and binds to SHP-2 in human gastric mucosa. J. Infect. Dis. 187(2): 334-7 (2003) [Abstract-MEDLINE]

▲ページの先頭へ

2002

  1. Higashi, H., Tsutsumi, R., Fujita, A., Yamazaki, S., Asaka, M., Azuma, T. and Hatakeyama, M. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc. Natl. Acad. Sci. U. S. A. 99: 14428-33 (2002) [Abstract-MEDLINE]
  2. Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M. and Hatakeyama, M. SHP-2 Tyrosine Phosphatase As an Intracellular Target of Helicobacter pylori CagA Protein. Science 295: 683-6 (2002)/ [Abstract-MEDLINE]
  3. Hatakeyama, M. Helicobacter pylori CagA-a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins. Microbes Infect. 5(2): 143-50 (2003) [Abstract-MEDLINE]
  4. Hatakeyama, M. Dereguration of SHP-2 tyrosine phosphatase by the Helicobacter pylori virulence factor CagA. Keio J. Med. Suppl 2: 26-32 (2002) [Abstract-MEDLINE]
  5. Tono-oka, S. and Hatakeyama, M. Unusual enzymatic hydrolysis of NAD by solubilized form of NAD(+) glycohydrolase. Chem. Pharm. Bull. 50(6): 831-3 (2002) [Abstract-MEDLINE]
  6. Yamada, M., Kondo, T., Ashizawa, S., Takebayashi, T., Higashi, H. and Hatakeyama, M. Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferation. Cytokine 17(2): 91-7 (2002) [Abstract-MEDLINE]

▲ページの先頭へ

2001

  1. Ashizawa, S., Nishizawa, H., Yamada, M., Higashi, H., Kondo, T., Ozawa, H., Kakita, A. and Hatakeyama, M. Collective Inhibition of pRB Family Proteins by Phosphorylation in Cells with p16INK4a Loss or Cyclin E Overexpression. J. Biol. Chem. 276(14): 11362-70 (2001) [Abstract-MEDLINE]
  2. Kondo, T., Higashi, H., Ishikawa, S., Ashizawa, S., Yamada, M., Makita, Z., Koike, T. and Hatakeyama, M. Involvement of pRB-Related p107 Protein in the Inhibition of S-Phase Progression in Response to Genotoxic Stress. J. Biol. Chem. 276(20): 17559-67 (2001) [Abstract-MEDLINE]
  3. Tono-oka, S. and Hatakeyama, M. O-ADP-Ribosylation in the NAD/NADase system: 2-alkanols as efficient substrates. Chem. Pharm. Bull. 49: 123-125 (2001) [Abstract-MEDLINE]

▲ページの先頭へ

2000

  1. Ohtoshi, A., Maeda, T., Higashi, H., Ashizawa, S., Yamada, M., and Hatakeyama, M. beta3-endonexin as a novel inhibitor of cyclin A-associated kinase. Biochem. Biophys. Res. Comm. 267: 947-952 (2000) [Abstract-MEDLINE]
  2. Ohtoshi, A., Maeda, T., Higashi, H., Ashizawa, S., Yamada, M. and Hatakeyama, M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by cyclin A-Cdk2 complex. Biochem. Biophys. Res. Comm. 268: 530-534 (2000) [Abstract-MEDLINE]
  3. Aso, T., Yamazaki, K., Amimoto, K., Kuroiwa, A., Higashi, H., Matsuda, Y., Kitajima, S. and Hatakeyama, M. Identification and Characterization of Elongin A2, a new member of the elongin family of transcription elongation factors, specifically expressed in the testis. J. Biol. Chem. 275: 6546-6552 (2000) [Abstract-MEDLINE]
  4. Mizuguchi, R., Noto, S., Yamada, M., Ashizawa, S., Higashi, H. and Hatakeyama, M. Ras and signal transducer and activator of transcription (STAT) are essential and sufficient downstream components of JAKs in cell proliferation. Jpn. J. Cancer Res. 91(5): 527-33(2000) [Abstract-MEDLINE]

▲ページの先頭へ

1999

  1. Shinobu, N., Maeda, T., Aso, T., Ito, T., Kondo, T., Koike, K. and Hatakeyama, M. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J. Biol. Chem. 274: 17003-17010 (1999) [Abstract-MEDLINE]
  2. Mori, A., Higashi, H., Hoshikawa, Y., Imamura, M., Asaka, M. and Hatakeyama, M. Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue. Oncogene 18: 6209-6221 (1999) [Abstract-MEDLINE]
  3. Aso, T., Amimoto, K., Takebayashi, S-I., Okumura, K. and Hatakeyama, M. Structural organization and chromosome location of the mouse elongin A gene (Tceb3). Cytogenet. Cell Genet. 86: 259-262 (1999) [Abstract-MEDLINE]
  4. Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, k., Higashi, H., Nakano, H., Okumura, K., Good R. A., Nakayama, K. Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1. Proc. Natl. Acad. Sci. U. S. A. 96: 3859-3863 (1999) [Abstract-MEDLINE]
  5. Tono-oka, S., Azuma, I. Terminal diols as efficient substrates for transglycosylational activity of NAD glycohydrolase. Nucleosides and Nucleotides 18: 39-49 (1999) [Abstract-MEDLINE]

▲ページの先頭へ

1998

  1. Hoshikawa, Y., Amimoto, K., Mizuguchi, R. and Hatakeyama, M. Highly controlled heterologous gene expression through combined utilization of the tetracycline-repressible transactivator and the lac repressor. Anal. Biochem. 261: 211-218 (1998) [Abstract-MEDLINE]
  2. Iwabe, K., Teramura, M., Yoshinaga, K., Kobayashi, S., Hoshikawa, Y., Maeda, T., Hatakeyama, M. and Mizoguchi, H. K-252a-induced polyploidization and differentiation of a human megakaryocytic cell line, Meg-J: transient elevation and subsequent suppression of cyclin B1 and cdc2 expression in the process of polyploidization. British J.Haematol. 102: 812-819 (1998) [Abstract-MEDLINE]
  3. Hoshikawa, Y., Mori, A., Amimoto, K., Iwabe, K. and Hatakeyama, M. Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130. Proc. Natl. Acad. Sci. U. S. A. 95: 8574-8579 (1998) [Abstract-MEDLINE]
  4. Mizuguchi, R. and Hatakeyama, M. Conditional activation of Janus kinase (JAK) confers factor independence upon interleukin-3-dependent cells. Essential role of Ras in JAK-triggered mitogenesis. J. Biol. Chem. 273: 32297-32303 (1998) [Abstract-MEDLINE]
  5. Noto, S., Maeda, T., Hattori, S., Inazawa, J., Imamura, M., Asaka, M. and Hatakeyama, M. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. FEBS Letters 441: 127-131 (1998) [Abstract-MEDLINE]
  6. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi,H., Kitagawa, M., Nakayama, K., Saito, Y., Hirai, A. Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. J. Biol. Chem. 273: 26772-26778 (1998) [Abstract-MEDLINE]
  7. Yoo, Y.C., Yoshimatu, K., Koike, Y., Hatsuse, R., Yamanishi, K., Tanishita, O., Tono-oka, S., Arikata, J and Azuma, I. Adjuvant activity of muramy dipeptide derivatives to enhance immunogenicity of a hantaanvirus inactivated vaccine. Vaccine 16: 216-224 (1998) [Abstract-MEDLINE]
  8. Kikuchi, M., Yoshimatsu, K., Arikawa, J., Y. C. Yoo., Isegawa, Y., Tono-oka, S. and Azuma, I. Characterization of neutralization monoclonal antibody escape mutants of hantaan virus 76118. Arch.Virol. 143: 73-83 (1998) [Abstract-MEDLINE]
  9. Koike, Y., Yoo, Y. C., Mitobe, M., Watanabe, R., Okumura, K., Tono-oka,S. and Azuma, I. Enhancing activity of mycobacterial cell-derived adjuvants on immunogenicity of recombinant human hepatitis B virus vaccine. Vaccine 16: 1982-1989 (1998) [Abstract-MEDLINE]